Managing tumor lysis syndrome

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Managing tumor lysis syndrome in 2010.

In this issue of Leukemia and Lymphoma, Darmon et al. report that patients with renal injury manifest by an acute rise in serum creatinine or the development of oliguria without a rise in the serum creatinine (presumably insufficient time has elapsed for creatinine to accumulate in the serum) have a significantly shorter survival than patients who develop tumor lysis syndrome but maintain adequ...

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Tumor Lysis Syndrome

Hospital Physician September 2008 25 T umor lysis syndrome (TLS) is a collection of metabolic abnormalities that occur as a result of the release of intracellular contents following lysis of malignant cells, typically after initiation of chemotherapy. The features of TLS include hyperphosphatemia, hyperuricemia, hypocalcemia, hyperkalemia, and acute kidney injury. These features are observed wh...

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Spontaneous Tumor Lysis Syndrome

Tumor lysis syndrome (TLS) is a known complication of malignancy and its treatment. The incidence varies on malignancy type, but is most common with hematologic neoplasms during cytotoxic treatment. Spontaneous TLS is thought to be rare. This case study is of a 62-year-old female admitted with multisystem organ failure, with subsequent diagnosis of aggressive B cell lymphoma. On admission, labo...

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The tumor lysis syndrome.

From the Department of Oncology and International Outreach Program, St. Jude Children’s Research Hospital (S.C.H., C.-H.P.), and the Department of Pediatrics, University of Tennessee Health Sciences Center, College of Medicine (S.C.H., D.P.J., C.-H.P.) — both in Memphis. Address reprint requests to Dr. Howard at St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Barry-Longinotti Bld...

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Oncologic Emergencies: Tumor Lysis Syndrome

The tumor lysis syndrome (TLS), characterized by hyperkalemia, hyperuricemia, hyperphosphatemia and secondary hypocalcemia, is a consequence of treatmentinduced or spontaneous tumor cell death. It usually occurs a few hours to a few days after commencing cytotoxic chemotherapy for tumors with a high percentage of proliferating and drug-sensitive cells. Cell death leads to the release of potassi...

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ژورنال

عنوان ژورنال: Journal of the American Academy of Physician Assistants

سال: 2021

ISSN: 1547-1896

DOI: 10.1097/01.jaa.0000723908.23506.85